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Senior bioinformatician (M/F) Positions to be filled : Soon as possible Type of job : Permanent contract Type of activity : Scientific teams Ad type : ICM

POSITION

Context

The Data Analysis Core facility (DAC) is a core facility of the Paris Brain Institute that supports researchers in the discovery of new insights and treatments in the field of neurological diseases and disorders. The DAC consists of an enthusiastic interdisciplinary team of experts in biostatistics, bioinformatics, image analysis, and data managers. We accompany researchers throughout the research cycle, by providing robust and reproducible analyses, expert advice, training, and the development of new solutions for emerging technologies. If you are interested in the brain and want to contribute to discoveries in a stimulating research environment, the DAC could be the place for you.

 

Missions

We are looking for senior bioinformatician to reinforce our ability to tackle the questions of today. The fast-evolving field requires initiative to find solutions, and a sensitivity to quality control, communication with research teams, and teamwork. Technical expertise and experience in several omics modalities are needed to meet the increasingly complex and multimodal bioinformatics approaches. As a member of our omics analysis team, you will be responsible for the translation of biological questions into actionable insights through bioinformatics analyses. You will be expected to be independent in managing multiple projects simultaneously, ensuring quality through regular rapports and communication with research teams under the supervision of our omics team manager and supported by the team’s project manager.

  • Provide support to research teams in the analysis and interpretation of (multi)omics data, including (but not limited to) scRNAseq and Spatial Transcriptomics.
  • Participate in developments of bioinformatics pipelines and workflows for (multi)omics data analysis, ensuring accuracy, reproducibility, and scalability.
  • Collaborate with computational biologists, geneticists, and clinicians to integrate (multi)omics data and facilitate translational research efforts.
  • Stay updated with the latest advancements in omics technologies, bioinformatics tools, and analytical methods, and contribute to the continuous improvement of data analysis workflows.

 

 

PROFILE

 

Know-how

  • Expertise in the analysis of several omics data types, e.g. spatial transcriptomics, single-cell and/or bulk RNA sequencing, single-cell and/or bulk ATAC sequencing, proteomics, WGS/WES sequencing, methylation data, CHIPseq.
  • Experience in complex experimental designs, e.g. non-custom references, multi-omics data integration, and integration of multiple variables in bulk designs.
  • Proficiency in UNIX environments (shell).
  • Proficiency in R (required), and Python (desired), in a version-controlled setting (Git).
  • Proficiency in data visualization.
  • Professional experience of at least four years in the field of omics analysis in academia or industry.
  • Proven experience in routine and complex omics analyses.
  • Proven experience in communicating and interpreting results for researchers/biologists.
  • Academic reading, writing, and conversational skills in English (required) and French (desired).

 

Knowledge

  • Minimum Bac+5 (master or engineer) in bioinformatics, or equivalent level in biology/computing.
  • Training in omics analyses, including but not limited to, batch effect correction, differential expression, pathways enrichment, trajectory analyses, and deconvolution.

 

Soft skills

  • Ability to work in a team according to common procedures.
  • Autonomy, initiative, and flexibility in finding solutions for new and unexpected issues.
  • Ability to communicate with people from various scientific and technical backgrounds.
  • Motivation to advance research in neuroscience!

 

Conditions

  • Remuneration: according to the level of study and experience.

 

 

Please send your CV and letter of motivation (in English), indicating name and contact details of two references (incomplete dossiers will not be considered) to recrutement@icm-institute.org and marie.coutelier@icm-institute.org with the subject: “Senior bioinformatician (M/F)”.

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Clinical Research Data Manager (M/F) Positions to be filled : Soon as possible Type of job : Permanent contract Type of activity : Scientific teams Ad type : ICM

POSITION

Context

The Paris Brain Institute engages increasingly in large multi-cohort, multi-central transversal clinical research studies that aim to allow integrated data exploration and prediction models across diverse sets of retrospective and prospective clinical research databases, integrating multimodal data from neuroimaging, biological samples, and omics. These studies require long-term solutions that ensure interoperability across the diversity of research data. The Data Analysis Core facility (DAC) supports researchers throughout this process by providing robust and reproducible analysis and data management solutions. If you are interested in data, biology and neuroscience and want to contribute to discoveries in a stimulating research environment, the DAC could be the place for you.

 

Missions

We are currently looking for data managers to help us manage a diversity of clinical data collected and analyzed at the institute, as part of multimodal studies that integrate neuroimaging, microscopy, electrophysiology, behavior data and biological samples. You will be responsible for designing electronic data capture within REDCap in close collaboration with research teams, data acquisition platforms, project managers and engineers, under the supervision and – supported by – our clinical research data manager. You will be part of ambitious programs aimed at discovering new insights and treatments for neurological diseases and neurodegenerative disorders, by reinforcing Good Clinical Practices in data science within a transversal team that includes IT, Legal office, Data Protection Officer, support for human studies (RIPH), and risk assurance. Your tasks will include:

  • Using REDCap to design eCRFs.
  • Design and perform quality control of large cohort clinical research databases using built-in solutions and where needed develop your own.
  • Administrate and perform maintenance on REDCap databases.
  • Implement solutions to ensure consistency of REDCap databases with multi-modal data, including neuroimaging and multi(omics).
  • Implement harmonization and interoperability across (retrospective) clinical research databases.
  • Optimize user-interfaces in REDCap.
  • Document processes, including guidelines for clinical research data management.

 

 

PROFILE

 

Know-how

  • Hands-on experience in the use and configuration of REDCap or other eCRF systems (highly desired)
  • Experience in Good Clinical Practices (GCP), i.e. Bonnes Pratiques Cliniques (BPC)
  • Programming experience in markup languages desired, especially in HTML
  • Professional experience in a research environment (academic or industry)
  • Understanding digital tools for data management and (clinical) research databases (e.g., REDCap, CDISC)
  • Understanding of clinical research ontologies (e.g. BioPortal, FHIR)
  • English and/or French language skills

 

Knowledge

 

  • Master’s degree or higher in data management, bioinformatics, biotechnology, or related field

 

Soft skills

  • Autonomy and initiative, with a hands-on attitude
  • Excellent organizational and project management skills
  • Flexible and solution-oriented with the ability to communicate with researchers and staff from different backgrounds and with different needs, timetables, and understanding.

 

Conditions

  • Remuneration: according to the level of study and experience

 

 

Please send your CV and letter of motivation (in English), indicating name and contact details of two references (incomplete dossiers will not be considered) to recrutement@icm-institute.org and stephen.whitmarsh@icm-institute.org with the subject: “Clinical Research Data Manager M/F”.

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