member

Previous page Stéphanie BAULAC PhD, DR2, INSERM Team “Genetics and physiopathology of epilepsy” https://www.baulacleguernepilepsy.com/

Biography

Stéphanie Baulac is leader of the team “Genetics and physiopathology of epilepsy » (co-lead). She received a M.Sc. in human genetics in 1998, and a Ph.D. in Neurogenetics of the University Paris V René Descartes in 2001. She received in 2014 the Valerie Chamaillard Prize, an award from the French foundation for the research on epilepsy. In 2016, she was awarded an ERC consolidator grant. In 2019, she has been awarded the international Michael Prize, recognizing her significant contributions to the field of epilepsy (prize shared with B. Frauscher). Stéphanie is the scientific director of the iGenSeq (Genotyping and Sequencing Core) Facility of ICM.

Research work

Familial focal epilepsies & Focal epilepsies associated to malformations of cortical development such as Focal Cortical Dysplasia (FCD).

Stéphanie BAULAC’s team investigates the focal epilepsies linked to the mTORC1 pathway through three main aims:
  • Assess the role and origin of brain somatic mutations in epilepsies with malformations of cortical development
  • Investigate the effect of mutations using patient’s iPSCs
  • Understand how mutations in the mTOR pathway genes contribute to epileptogenesis and seizures using mice models (in utero electroporation focal models and knockouts)

Publications