member

Previous page Michel MALLAT Director of Research at INSERM Team “Genetics and development of nervous system tumors”

Biography

Michel Mallat is a research director at INSERM. He holds a PhD in Neuropharmacology from the University Pierre et Marie Curie (1984), a PhD in Medicine (1987) and has been directing research focused on the development or functions of microglial cells since 1989. He is an external expert reader for several international scientific journals and participates in the teaching of neuroscience at Master level.

Research work

Michel Mallat specialises in the study of microglial cells. His current work focuses on the activation and functions of microglial cells in acute or chronic neuroinflammatory contexts including brain tumours. In connection with public health issues, he coordinates multicentre research programmes focusing on the impact of physical environmental agents on neuroinflammatory reactions.

Publications

Occelli F, Lameth J, Adenis V, Huetz C, Lévêque P, Jay TM, Edeline JM, Mallat M. A single exposure to GSM- 1800 MHz signals in the course of an acute neuroinflammatory reaction can alter neuronal responses and microglial morphology in the rat primary auditory cortex. Neuroscience 2018; 385:11-24. Mesci P, Zaïdi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, Sato H, Mallat M, Boillée S System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Brain. 2015 Jan;138(Pt 1):53-68. Lelli A, Gervais A, Colin C, Cheret C, Nunez Figueiredo S, Ruiz de Almodovar C, Carmeliet P, Van Rooijen N, Krause KH, Boillee S, Mallat M. The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R- mediated microglia chemotaxis and promotes early infiltration of phagocytes in the subentricular zone of the mouse cerebral cortex. GLIA 2013; 61:1542-55. Cheret C, Gervais A, Lelli A, Colin C, Amar L, Ravassard P, Mallet J, Cumano A, Krause KH, Mallat M. Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci 2008;28(46):12039-51 Marin Teva JL, Dusart I, Colin C, Gervais A, Van Rooijen N, Mallat M. Microglia promote the death of developing Purkinje Cells. Neuron. 2004;41:535-47.