member

Previous page Jaime DE JUAN-SANZ PhD The Diane Barrière Chair « Molecular physiology of synaptic bioenergetics » http://www.dejuansanzlab.org https://twitter.com/https://twitter.com/JaimedeJuan https://www.linkedin.com/in/jaime-de-juan-sanz-18b1ab71/?originalSubdomain=fr

Biography

Following his graduate studies in Molecular Neurobiology at the Center of Molecular Biology Severo Ochoa (Madrid, Spain), Jaime joined in 2013 the lab of Dr. Timothy A. Ryan at Weill Cornell Medical College for his postdoc where he worked on developing novel tools to study the role of presynaptic organelles in synaptic transmission. In 2019 Jaime was recruited as independent Team Leader at the Paris Brain Institute (France), where he currently leads a laboratory focused on developing cutting-edge optical tools to better understand the molecular mechanisms controlling synaptic transmission. His research is supported by a European Research Council (ERC) Starting Grant, an ATIP-avenir grant (Inserm, CNRS, France) and the Diane Barrière Chair in Synaptic Bioenergetics (Paris Brain Institute, France). The de Juan-Sanz lab aims to understand the molecular underpinnings controlling synaptic function to ultimately dissect how its dysregulation affects brain physiology and impacts human disease. We use and develop cutting-edge optical tools to examine diverse aspects of the biology of synapses, aiming to develop a detailed picture of the molecular mechanisms controlling synaptic transmission. Among these tools, we aim to design novel tools to precisely measure Ca2+ dynamics in neuronal organelles such as the endoplasmic reticulum, mitochondria or lysosomes. Another main axis of the lab is focused on understanding the role of metabolism and bioenergetics in supporting synaptic function, dissecting the molecular mechanisms that support and coordinate local energy expenditure and production to preserve the metabolic integrity of synapses. The overarching goal of the lab is to provide actionable knowledge that can be used to design better strategies for screening, prevention and treatment of human diseases. We collaborate with physicians at the Pitié-Salpêtrière Hospital to study human brain physiology and to increase our understanding on the synaptic molecular drivers of epilepsy and other neurological diseases.

Research work

Our lab aims to understand the molecular underpinnings controlling synaptic function to ultimately dissect how its dysregulation affects brain physiology and impacts human disease. We use cutting-edge optical tools to examine diverse aspects of the biology of synapses to develop a detailed picture of the molecular mechanisms controlling synaptic transmission. Our overarching goal is to provide actionable knowledge that can be used to design better strategies for screening, prevention, and treatment of human diseases. We collaborate with physicians at the Pitié-Salpêtrière Hospital to study human brain physiology and to increase our understanding on the synaptic molecular drivers of epilepsy and other neurological diseases.

Publications

  • de la Rocha-Muñoz A., Núñez, E., Gómez-López, S., López‐Corcuera, B., de Juan-Sanz J* and Aragón, C (2020). The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo. * Corresponding author. BioRxiv.
  • Ashrafi, G.*, de Juan-Sanz, J*, Farrell, R.J. and Ryan T.A. (2020). Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission. Neuron, 105(4), 678-687.. * Co-first authors.
  • de la Rocha-Muñoz A., Núñez, E., Arribas-González, E., López‐Corcuera, B., Aragón, C* and de Juan-Sanz J* (2019). E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2. * Co-corresponding authors. Scientific Reports. 9, 14944
  • Koopmans F, van Nierop P, Andres-Alonso M, (…) Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, (…) Thomas PD, Smit AB, Verhage M (2019). SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron, 103(2):217-234
  • de Juan-Sanz, J., Holt, G. T., Schreiter, E. R., de Juan, F., Kim, D. S., & Ryan, T. A. (2017). Axonal endoplasmic reticulum Ca 2+ content controls release probability in CNS nerve terminals. Neuron, 93(4), 867-881.