Team “Cellular and molecular approaches for myelin repair” - Institut du Cerveau et de la Moelle Epinière

Presentation

Based on complementary expertises in oligodendrocyte regeneration (B. Nait-Oumesmar), neuro-inflammation (V. Zujovic) and stem cell biology (A. Baron-Van Evercooren), the common goal of team is to provide a better understanding of the cellular and molecular mechanisms involved in myelin regeneration and to develop innovative therapies enhancing remyelination and providing effective neuroprotection for demyelinating disorders.

Major publications

El Behi M, Sanson C, Bachelin C, Guillot-Noël L, Fransson J, Stankoff B, Maillart E, Sarrazin N, Guillemot V, Abdi H, Cournu-Rebeix I, Fontaine B, Zujovic V (2017). Adaptive human immunity drives remyelination in a mouse model of demyelination. Brain, in press. (equally contributed).
Wegener A, Deboux C, Bachelin C, Frah M, Kerninon C, Seilhean D, Weider M, Wegner M, Nait-Oumesmar B. Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination. Brain.
Mozafari S, Laterza C, Roussel D, Bachelin C, Marteyn A, Deboux C, Martino G, Baron-Van Evercooren A. Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice. J Clin Invest.
Hammond TR, Gadea A, Dupree J, Kerninon C, Nait-Oumesmar B, Aguirre A, Gallo V (2014) Astrocyte-derived endothelin-1 inhibits remyelination through notch activation. Neuron.
Blanchard B, Heurtaux T, Garcia C, Moll NM, Caillava C, Grandbarbe L, Klosptein A, Kerninon C, Frah M, Coowar D, Baron-Van Evercooren A, Morga E, Heuschling P, Nait Oumesmar B. Tocopherol derivative TFA-12 promotes myelin repair in experimental models of multiple sclerosis. J Neurosci.