Équipe Scientifiques

Previous page Brahim NAIT OUMESMAR PhD, DR2, INSERM Team “Myelin plasticity and regeneration”


Brahim Nait Oumesmar joined the ICM in 2009, where is the leader of the team “Cellular and Molecular Approaches for Myelin Repair” and coordinator of the IHU-A-ICM workpackage on Multiple Sclerosis and of the NeurATRIS program on Drug Screening. He received a PhD in Neurosciences at the University Pierre & Marie Curie (1997) and then did a post-doctoral training in Developmental Neurobiology at the Mount Sinai School of Medicine (New York, NY, USA) from 1997 to 2002, where is he was appointed Research Assistant Professor. He is member of several scientific boards and Elected President of the French Club of Glial Cells. He is expert of grants for the Multiple Sclerosis Societies (Australia, UK, USA, France), MRC and Biological Sciences Research Council (UK). Brahim Nait Oumesmar is also member of the ENP Graduate Program committee and scientific advisor for MS foundations.

Research work

Oligodendrocyte development and regeneration.

Brahim NAIT OUMESMAR & Violetta ZUJOVIC’s team aims at providing better insight into the mechanisms of myelin plasticity and regeneration. Compelling evidences indicate that oligodendrocyte progenitor cells (OPCs) sense neuronal activity and immune cells signaling, highlighting the importance of these crosstalk’s in (re)-myelination. Therefore, our research project will rely on three major aims to decipher:
  • The role of i)neuronal activity and ii) immune cells in oligodendrocyte differentiation, regeneration and myelin repair, unraveling their relevance in human oligodendrocyte differentiation;
  • To develop innovative tools to identify and assess the therapeutic value of new pro-myelinating compounds.