Big Brain Theory Program launched in 2015. This call puts a high priority on individual creativity, allowing scientists to launch risky, “thinking out the box” projects, and on cross-disciplinary teamwork projects proposed by researchers, clinicians,...
Myelin, a protective sheath that covers various nerve fibers, is essential in the transmission of nerve signals and enables proper function of the nervous system. Myelin degeneration causes severe illnesses including multiple sclerosis. Lamia...
The emergence of multidisciplinary, bold and innovative original research projects carried out by the ICM’s young talents, thanks to the Bolloré Group support, is the ICM's Brain Booster Challenge bet.
2010-2015 : 12 major scientific advances
Main domain: Cellular & molecular neurosciences
Subdomain : Clinical & translational neurosciences
Brahim Nait Oumesmar & Violetta ZUJOVIC’s team aims at providing better insight into the mechanisms of myelin plasticity and regeneration. Compelling evidences indicate that oligodendrocyte progenitor cells (OPCs) sense neuronal activity and immune cells signaling, highlighting the importance of these crosstalk’s in (re)-myelination. Therefore, our research project will rely on three major aims to decipher:
The role of i)neuronal activity and ii) immune cells in oligodendrocyte differentiation, regeneration and myelin repair, unraveling their relevance in human oligodendrocyte differentiation;
To develop innovative tools to identify and assess the therapeutic value of new pro-myelinating compounds.