Stem cells core facility
Scientific manager: BOHL Delphine (PhD, CR1, INSERM)
Operational manager: Stéphanie BIGOU (Engineer)
To model in a culture dish degenerative disorders of the brain and the spinal cord, CELIS-iPS produces Human induced-pluripotent stem (iPS) cells. This aim is to better investigate the molecular and cellular mechanisms underlying these disorders and to develop a screening approach for drugs of therapeutical interest. The specific goals of the platform are three-fold:
- 1 – To generate and characterize iPS cells through genetic reprogramming of skin cells from patients and healthy volunteers
- 2 – To correct or introduce mutations of interest using appropriate genetic tools
- 3 – To create a repository of disease-specific iPS cells.
The IHU-A-ICM supports this activity.