Cell culture core facility
Scientific manager: Patrick Pierre MICHEL (PhD)
Operational manager: Laetitia STREHL (Engineer)
This core facility makes available a large panel of cell and tissue culture models and up-to-date equipment to academic researchers, biotech companies and industrials that pursue experimental projects on pathologies of the brain and spinal cord. Specific activities operated by CELIS staff include, automated and conventional fluorescence imaging, automated cell culture, electrophysiological recordings and induced pluripotent stem (iPS) cell production/characterization. The facility is part of the ICM core facility network and supported by “Investissements d’avenir” IHU-A-ICM and NeurATRIS.
Electrophysiology core facility
Scientific manager: Carine DALLE (PhD)
Operational manager: Charlotte DELEUZE (Engineer)
CELIS-ePhys is an unique core facility providing high quality contract research services to academics and pharmaceutical industry requiring in vitro and ex vivo electrophysiology technique for successful completion of neurosciences studies. The facility is equipped for both patch-clamp and field potential recordings. The facility is involved in many different research project as diverse as the studies of channelopathies, human iPSC derived neurons and neural plasticity. The IHU-A-ICM funding supports this activity.
Stem cells core facility
Scientific manager: BOHL Delphine (PhD, CR1, INSERM)
Operational manager: Stéphanie BIGOU (Engineer)
To model in a culture dish degenerative disorders of the brain and the spinal cord, CELIS-iPS produces Human induced-pluripotent stem (iPS) cells. This aim is to better investigate the molecular and cellular mechanisms underlying these disorders and to develop a screening approach for drugs of therapeutical interest. The specific goals of the platform are three-fold:
- 1 – To generate and characterize iPS cells through genetic reprogramming of skin cells from patients and healthy volunteers
- 2 – To correct or introduce mutations of interest using appropriate genetic tools
- 3 – To create a repository of disease-specific iPS cells.
The IHU-A-ICM supports this activity.
Histology core facility
Scientific manager: Benoit DELATOUR (PhD, CR1, CNRS)
Operational manager: Annick PRIGENT (Engineer)
Histomics is a technical support center open to researchers of the ICM and to academic/ industrial partners. It is accessible on a space-rent or service basis and uses standardized protocols and up-to date equipment for the processing of histological (animal and human) material. The staff offers technical and scientific support and services, to train users to histological techniques and to perform work for specific projects. Histomics facilitates translational research projects.