The vectorology platform produces viral tools for highly concentrated gene transfer at different scales. iVector is specialized in lentiviral systems because it benefits from the in-house experience of the biotechnology and biotherapy team of the Brain Institute – ICM/CNRS. The use of adenoviruses and AAV systems in the field of neurobiology research is constantly increasing. iVector has developed the production of AAV serotypes 2, retro2 & 9 in addition to its lentiviral system. The platform makes these tools available to all academic and industrial partners. iVector is constantly implementing innovative gene transfer technologies (CRISPR, split-reporters, DNA/RNA-based libraries, etc.) in its portfolio of services, enabling new approaches in basic research and leading to new applications in genetic engineering, curative and regenerative medicine (gene and cell therapy, tissue engineering and vaccines). iVector’s facilities for the production and handling of viral particles have been designed to meet biosafety level 2 (L2) and biosafety level 3 (L3) in accordance with national and European regulations. The platform has been developing for many years a large and diverse collection of viral vectors that allows to quickly provide a solution adapted to the needs of researchers for their in vitro and in vivo applications. iVector is part of the Brain Institute’s network of technological platforms (genotyping, histology, microscopy, cell culture…) that facilitates translational research projects.
ACTIVITIES
• Customized services: Lentiviral systems, design, construction of AAV viral vectors and production of viral particles for research open to academic and industrial partners.
• Our viral vector tools are intensively used for: Cell and tissue transductions (brain, CNS, …); In vivo viral transgenesis (mouse, rat, animal models); Immortalization of primary cells; Stem cell transduction, iPS; Knock-in, knock-out, cell tagging, gene silencing, CRISPR; Constitutive and inducible expression, cell or tissue specific expression; Gene and cell therapy, cell engineering, vaccines.
• Scientific and technical advice for the design and production of viral vectors.
• Provision of equipment and L2 and L3 laboratories.
CERTIFICATION
The activities of the Vectorology platform have been certified since 2015 regarding the ISO9001 standard (out of equipments provision activity), allowing to guarantee the traceability, the reliability and the rigour of the implemented procedures. »