Previous page Nicole FAUCON-BIGUET Senior researcher INSERM, scientific adviser Team "Biotechnology et biotherapy" (Bio-Modeling in Neurodegenerative Diseases)


Nicole Faucon Biguet obtained a PhD in virology at the University of Lyon, France. After this training in biology and virology she was interested by the molecular biology developments in the field of neurobiology. In this perspective, she carried out with the group of Jacques Mallet the first cloning of a neurotransmission-related gene: the tyrosine hydroxylase, coding for the rate-limiting enzyme in the synthesis of catecholamines. Thereafter, she has actively contributed to the cloning of other genes coding for several enzymes implicated in the synthesis of different neurotransmitters. In the follow-up of her scientific work, she is presently collaborating with Rolando Meloni on the generation of animal models for the functional studies of genes implicated in neuropsychiatric diseases, particularly Parkinson’s disease.


  • Lamouroux, A., Faucon Biguet, N., Samolyk, D., Privat, A., Salomon, J. C., Pujol, J. F., and Mallet, J. (1982). Identification of cDNA clones coding for rat tyrosine hydroxylase antigen. Proc Natl Acad Sci U S A, 79, 3881-3885.
  • Faucon Biguet, N., Buda, M., Lamouroux, A., Samolyk, D., and Mallet, J. (1986). Time course of the changes of TH mRNA in rat brain and adrenal medulla after a single injection of reserpine. EMBO J, 5, 287-291.
  • Faucon Biguet, N., Rittenhouse, A. R., Mallet, J., and Zigmond, R. E. (1989). Preganglionic nerve stimulation increases mRNA levels for tyrosine hydroxylase in the rat superior cervical ganglion. Neurosci Lett, 104, 189-194.
  • Vyas, S., Faucon Biguet, N., and Mallet, J. (1990). Transcriptional and post-transcriptional regulation of tyrosine hydroxylase gene by protein kinase C. EMBO J, 9, 3707-3712.
  • Icard-Liepkalns, C., Faucon Biguet, N., Vyas, S., Robert, J. J., Sassone-Corsi, P., and Mallet, J. (1992). AP-1 complex and c-fos transcription are involved in TPA provoked and trans-synaptic inductions of the tyrosine hydroxylase gene: insights into long-term regulatory mechanisms. J Neurosci Res, 32, 290-298
  • Albanese, V., Faucon Biguet, N., Bayard, E., Kiefer, H., Mallet, M., and Meloni, R. (2001). Quantitative effects on gene silencing by allelic variations of a tetranucleotidic microsatellite. Hum Mol Gen, 17, 1785-1792.
  • Aranyi, T., Faucheux, B., KhalfAllah, O., Vodjdani, G., Faucon Biguet, N., Mallet, J., and Meloni, R. (2005). The tissue-specific methylation of the human tyrosine gene reveals new regulatory elements in the first exon .J of Neurochem, 94, 129-139.
  • Tejedor-Real, P., Sahagùn, M., Faucon-Biguet, N. and Mallet, J. (2007) Neonatal handling prevents the effects of phencyclidine in an animal model of negative symptoms of schizophrenia. Biol.Psychiatry, 61, 865-872. Epub 2006 Nov 27.
  • Khalfallah, O., N. Faucon Biguet, J. Nardelli, R. Meloni and J. Mallet (2008). Expression of the transcription factor Zfp191 during embryonic development in the mouse. Gene Expr Patterns 8(3): 148-154. 
  • Ingallinesi, M., L. Le Bouil, N. Faucon Biguet, A. Do Thi, C. Mannoury la Cour, M. J. Millan, P. Ravassard, J. Mallet and R. Meloni (2015). Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats. Mol Psychiatry 20(8): 951-958.