Eric Leguern and Stephanie Baulac’s team are passionate about the familial epileptic syndromes which, additionally to being a significant health problem, are one of the most straightforward and reliable way to identify novel key proteins and pathways of epileptogenesis and ictogenesis. The main goal of the research is to understand the molecular and cellular mechanisms underlying genetic epilepsies, in particular familial focal epilepsies, focal cortical dysplasias, epileptic encephalopathies associated with febrile seizures, and genetic generalized epilepsies.
The research work combines high-throughput sequencing, transcriptomics, in utero electroporation, biochemistry, electrophysiology, and animal studies. Functional analyses are made on human postoperative tissue and neuronal cultures from specific rodent models. We apply modern techniques based on single-cell approaches, CRISPR/Cas9 editing, and multielectrode array recordings.
The team collaborates with several researchers in the USA (M. Meisler, M. Anderson) and in Japan (T. Mashimo, T. Serikawa) and is part of European projects and consortiums: the EPICURE project (2006-2011) and the EuroEPINOMICS consortium (since 2011). For more information