Gene therapyMain domain: Clinical & translational neurosciencesSubdomain : Molecular & cellular neuroscienceNathalie CARTIER’s team develops gene therapy strategies for severe neurodegenerative diseases including Huntington's disease, Spinocerebellar ataxias, Alzheimer's disease and genetic leukodystrophies. Research includes proof of concept in animal models and translational steps to clinical applications.
The team aims to propose a phase I/II therapeutic trial in 2020 for Huntington disease. The team will also develop tools for the delivery of therapeutic molecules in the brain (use of microglia, optimization of AAV for intravenous administration, optogenerapy for time-controlled delivery). For more information
Methodology and neuroimagingMain domain: Clinical & translational neurosciencesOlivier COLLIOT & Stanley DURRLEMAN’s team, the ARAMIS team aims to build numerical models of brain diseases from multimodal patient data based on the development of specific data-driven approaches.
The main research axes are
Integrate multimodal neuroimaging data (PET, microstructure, ASL) to fully characterize alterations
Model the temporal dynamics of disease
Model brain networks
Integrate imaging with other types of data (in particular omics and clinical data)