Research Teams

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Team “Molecular Pathophysiology of Parkinson’s disease”
Team leader(s)
Olga CORTI PhD, DR2, INSERM
Jean-Christophe CORVOL MD, PhD, PU-PH, Sorbonne University, AP-HP
Physiopathology of neurogical disorders
Main domain: Cellular & molecular neuroscience
Subdomain: Clinical & translational neurosciences

Olga CORTI & Jean-Christophe CORVOL’s team proposes a multidimensional clinical, genetic/genomic and cell biology-based program aimed at deciphering and integrating the molecular heterogeneity and biological complexity of Parkinson’s Disease (PD) towards translation to clinical research. For more information
TEAM “Structural dynamics of networks”
Team leader(s)
Nicolas RENIER PhD, CR1, INSERM
CNS development and plasticity
Main domain : Cellular & molecular neurosciences

Nicolas RENIER’s plans to develop and use cutting-edge 3D whole brain imaging and genetic tools aimed at elucidating how neuronal networks in the adult brain can be rewired at a large scale.
The team will :
  • Investigate the molecular mechanisms of axon and branch dynamics in the adult brain
  • Gain new information on neuro-vascular interaction during plastic events
  • Develop correlative 3D imaging of live calcium imaging in the behaving animal with whole brain mapping of neuronal markers and connectivity
  • Determine the role of structural plasticity to support transitions in behavior in the mouse.
For more information
Team “Brain Development”
Team leader(s)
Bassem HASSAN PhD, DR2, INSERM
CNS development and plasticity
Main domain : Cellular & molecular neurosciences

Bassem HASSAN’s team investigates the formation of neurons and neural circuits during brain development, focusing on the transcriptional control of stem cells fate during early neurogenesis in Drosophila and mouse, and the emergence of individuality in Drosophila visual circuits and behavior. For more information
Team “Genetics and physiopathology of epilepsy”
Team leader(s)
Stéphanie BAULAC PhD, DR2, INSERM
Eric LEGUERN MD, PhD, PU-PH, Sorbonne Université/APHP
Physiopathology of neurological disorders Main domain : Cellular & molecular neurosciences Subdomain : Clinical & translational neurosciences Stéphanie BAULAC & Eric LEGUERN’s team investigates the focal epilepsies linked to mTORC1 pathway, Focal cortical dysplasias, epileptic encephalopathies and genetic generalized epilepsies through three main aims:
  • To understand how mutations in the mTOR pathway genes contribute to epileptogenesis and seizures, and the role of brain somatic mutations
  • To characterize pathophysiological mechanisms of HCN1-epileptic encephalopathy, identify new genetic causes of fever-sensitive epileptic encephalopathies, and search for factors modulating the severity of the phenotype.
  • To explore how mutations found by the team in several presynaptic proteins lead to genetic generalized epilepsies (GGE).
For more information
Team “Alzheimer’s disease and prion diseases ”
Team leader(s)
Stephane HAIK MD, PhD, DR2, INSERM Contact by email
Marie-Claude POTIER PharmD, PhD, DR2, CNRS
Physiopathology of neurogical disorders
Main domain: Cellular & molecular neuroscience
Subdomain : Clinical & translational neurosciences

Marie-Claude Potier’s and Stéphane Haïk’s Team aims at understanding the role of lipids, particularly cholesterol and ApoE, in the secretion and neuronal transport, of AB, their involvement in endosomal modifications that occur early during the course of the disease and novel mechanisms of AB toxicity identified in vivo. For more information
Team “Repair in Multiple Sclerosis: from biology to clinical translation “
Team leader(s)
Catherine LUBETZKI MD, PhD, PU-PH, Sorbonne University, AP-HP
Bruno STANKOFF MD, PhD, PU-PH, Sorbonne University, AP-HP
Repair
Main domain: Cellular & molecular neuroscience
Subdomain : Clinical & translational neurosciences

Catherine LUBETZKI & Bruno STANKOFFs team aims to tackle the mechanisms of CNS myelin repair through complementary approaches and expertise in Multiple sclerosis and demyelinating disorders. For more information
Team “Experimental therapeutics of Parkinson’s disease”
Team leader(s)
Etienne HIRSCH PhD, DRCE, CNRS
Stephane HUNOT PhD, DR2, CNRS
Physiopathology of neurogical disorders Main domain: Cellular & molecular neuroscience Etienne HIRSCH & Stéphane HUNOT’s team aims to understand the mechanisms underlying disease progression in Parkinson Disease (PD) and to identify and validate new disease-modifying treatments. For more information
Team “Basic to translational neurogenetics”
Team leader(s)
Alexandra DURR MD, PhD, PU-PH, Sorbonne university-AP-HP
Giovanni STEVANIN PhD, DR2, PU, INSERM/EPHE
Physiopathology of neurological disorders
Main domain : Cellular & molecular neurosciences
Subdomain : Clinical & translational neurosciences

Alexandra DURR & Giovanni STEVANIN’s team focus on two groups of neurogenetic diseases, spinocerebellar degenerations – SCD (spastic paraplegias and cerebellar ataxias) and frontotemporal lobar degenerations – FTLD. These rare conditions share clinical, genetic and functional characteristics, such as motor neuron dysfunction but are extremely heterogeneous both in molecular and clinical aspects. For more information
Team “ALS : causes and mechanisms of motor neuron degeneration”
Team leader(s)
Severine BOILLEE PhD, CR1, INSERM
Physiopathology of neurological disorders Main domain : Cellular & molecular neurosciences Subdomain : Clinical & translational neurosciences Séverine BOILLEE’s team investigates mechanisms of motor neuron (MN) degeneration in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease) resulting from pathological interactions between MNs and microglia/macrophages to find therapeutically promising pathways to slow disease progression through two main aims: For more information
Team “Myelin plasticity and regeneration”
Team leader(s)
Brahim NAIT OUMESMAR PhD, DR2, INSERM
Violetta ZUJOVIC PhD, CR1, INSERM
Repair
Main domain: Cellular & molecular neurosciences
Subdomain : Clinical & translational neurosciences

Brahim NAIT OUMESMAR & Violetta ZUJOVIC’s team aims at providing better insight into the mechanisms of myelin plasticity and regeneration. Compelling evidences indicate that oligodendrocyte progenitor cells (OPCs) sense neuronal activity and immune cells signaling, highlighting the importance of these crosstalk’s in (re)-myelination. Therefore, our research project will rely on three major aims to decipher:
  • The role of i)neuronal activity and ii) immune cells in oligodendrocyte differentiation, regeneration and myelin repair, unraveling their relevance in human oligodendrocyte differentiation;
  • To develop innovative tools to identify and assess the therapeutic value of new pro-myelinating compounds.
For more information