Research Teams

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Team “Molecular physiology of synaptic bioenergetics”
Team leader(s)
Jaime DE JUAN-SANZ PhD, DR1
Neurophysiology
Main domain: Neurophysiology
Subdomain : Molecular & cellular neuroscience

Jaime DE JUAN-SANZ’s team investigates mitochondrial dysfunction as a primary cause in epilepsy. Mitochondria plays a pivotal role for neuronal function, controlling three fundamental mechanisms that are essential for neuronal biology and synaptic transmission: 1) ATP production, 2) Ca2+ homeostasis and 3) apoptotic cell death. Using cutting-edge optical techniques to study bioenergetics in firing synapses in combination with precise metabolic and genetic manipulations, the team will work on developing a detailed molecular understanding of the role of synaptic mitochondrial metabolism in controlling neuronal function in health and disease. For more information
Team “Cellular mechanisms of sensory processing”
Team leader(s)
Nelson REBOLA PhD, CR1, CNRS
Cellular physiology of cortical microcircuits
Main domain: Neurophysiology

Nelson REBOLA ‘s team aims to understand how the diversity in synaptic properties found between communicating neurons shapes information processing in the brain. Presently the team is investigating how variability in biophysical properties and synaptic densities of a particular subtype of glutamate receptor, the NMDA receptor, in somatosensory neurons impacts the processing of sensory information. For more information
Team “Cellular physiology of cortical microcircuits”
Team leader(s)
Alberto BACCI PhD, DR1, CNRS
Main domain : Neurophysiology

Alberto Bacci’s team investigates the microcircuits of the cerebral cortex. In particular, the team is interested in the synaptic and plasticity properties of synapses originating from a highly diverse population of neurons forming stereotyped cortical circuits. To this aim, the lab uses a battery of ex vivo and in vivo neurophysiological approaches. For more information
Team “Experimental neurosurgery”
Team leader(s)
Brian LAU PhD, CR1, CNRS
Carine KARACHI MD, PhD,MCU-PH, Sorbonne University, AP-HP
Basal ganglia, neurosurgery, movements disorders
Main domain: Neurophysiology
Subdomain: Clinical & translational neurosciences

Brain LAU & Carine KARACHI’s team aims to characterize the subcortico-cortical anatomy and physiology of brainnetworks involved in motor control, with the long-term goal of developing new therapies including novel applications of deep brain stimulation (DBS). For more information
Team “Dynamics of Epileptic Networks and Neuronal Excitability”
Team leader(s)
Stephane CHARPIER PhD, PU,Sorbonne university
Mario CHAVEZ PhD, CR1, CNRS
Vincent NAVARRO MD, PhD, PU-PH, Sorbonne university, AP-HP
Dynamics and physiopathology of neural networks, epilepsy
Main domain: Neurophysiology
Subdomain : Clinical & translational neurosciences

Stéphane CHARPIER, Mario CHAVEZ & Vincent NAVARRO ’s team investigates how the brain can become epileptic (epileptogenesis), how it produces seizures (ictogenesis), and the relationship between neurophysiological activities and clinical semiology. In addition, the team investigates extreme brain conditions with abnormal and sustained electrical activities (isoelectric status and status epilepticus). For more information
Team “Neurophysiology of Repetitive Behaviors”
Team leader(s)
Eric BURGUIERE PhD, CR1, CNRS
Basal ganglia, neurosurgery, movements disorders
Main domain: Neurophysiology
Subdomain : Cognition

Eric BURGUIERE’s team aims to implement an ambitious translational approach to characterize neurofunctional basis of normal and pathological repetitive behaviors. The main focus of the team is to study neurophysiological dynamics underlying the automatization of motivated behaviours and its contextual adaptation. The team has access to both patients and animal models suffering from pathological repetitive behaviors. For more information
Team “Normal and abnormal motor control: movement disorders and experimental therapeutics”
Team leader(s)
Stephane LEHERICY MD, PhD, PU-PH, Sorbonne University, AP-HP
Marie VIDAILHET MD, PU-PH, Sorbonne University, AP-HP
Basal ganglia, neurosurgery, movements disorders
Main domain: Neurophysiology
Subdomain: Clinical & translational neurosciences

Marie VIDAILHET & Stéphane LEHÉRICY’s team aims at further investigating network dysfunctions in movement and behavioral disorders using translational, neuroimaging, neurophysiological, and genetic/metabolic approaches from animals to patients. For more information
Team “Sensory Spinal Signaling ”
Team leader(s)
Claire WYART PhD, CR1, INSERM
Spinal circuits underlying locomotion
Main domain: Neurophysiology
Subdomain : Molecular & cellular neuroscience

Claire Wyart’s team investigates the neuromodulatory pathway coming from the brain and within the spinal cord and its effects on locomotion and posture. The team is interested in the circuits referred to as reticulospinal neurons (RSNs) that trigger locomotion in the hindbrain. For more information