Research Teams

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Team “Repair in Multiple Sclerosis: from biology to clinical translation “
Team leader(s)
Catherine LUBETZKI MD, PhD, PU-PH, Sorbonne University, AP-HP
Bruno STANKOFF MD, PhD, PU-PH, Sorbonne University, AP-HP
Repair
Main domain: Cellular & molecular neuroscience
Subdomain : Clinical & translational neurosciences

Catherine LUBETZKI & Bruno STANKOFFs team aims to tackle the mechanisms of CNS myelin repair through complementary approaches and expertise in Multiple sclerosis and demyelinating disorders. For more information
Team “Experimental therapeutics of Parkinson’s disease”
Team leader(s)
Etienne HIRSCH PhD, DRCE, CNRS
Stephane HUNOT PhD, DR2, CNRS
Physiopathology of neurogical disorders Main domain: Cellular & molecular neuroscience Etienne HIRSCH & Stéphane HUNOT’s team aims to understand the mechanisms underlying disease progression in Parkinson Disease (PD) and to identify and validate new disease-modifying treatments. For more information
Team “Gene Therapy”
Team leader(s)
Nathalie CARTIER MD, PhD, DRE, INSERM
Gene therapy
Main domain: Clinical & translational neurosciences
Subdomain : Molecular & cellular neuroscience

Nathalie CARTIER’s team develops gene therapy strategies for severe neurodegenerative diseases including Huntington's disease, Spinocerebellar ataxias, Alzheimer's disease and genetic leukodystrophies. Research includes proof of concept in animal models and translational steps to clinical applications.
The team aims to propose a phase I/II therapeutic trial in 2020 for Huntington disease. The team will also develop tools for the delivery of therapeutic molecules in the brain (use of microglia, optimization of AAV for intravenous administration, optogenerapy for time-controlled delivery). For more information
Team “Frontal functions and pathology”
Team leader(s)
Richard LEVY MD, PhD, PU-PH, Sorbonne university, AP-HP
Connectivity: frontal parietal,temporal and frontal-subcortical networks
Main domain: Cognition
Subdomain : Clinical & translational neurosciences

Richard LEVY’s team aims to better understand the role and organization of the PreFrontal Cortex (PFC) in the control, in activatory and inhibitory modes, of "willed/voluntary/conscious/goal-directed behaviors", its role as a controller and its involvement in the most “creative” aspects of thinking and how it functionally and structurally interacts with other brain structures. For that, the team will
  • Pursue projects on creativity, reasoning, apathy and brain networks
  • Expand onto some new fundamental topics, such as the neural basis of impulsivity, ecological study of goal-directed behavior and translational applications
  • Characterize and treat pathologies associated with impairments of frontal functions.
  For more information
Team “Physiological investigation of clinically normal and impaired cognition”
Team leader(s)
Paolo BARTOLOMEO MD, PhD, DR2, INSERM
Laurent COHEN MD, PhD, PU-PH, Sorbonne University, AP-HP
Lionel NACCACHE MD, PhD, PU-PH, Sorbonne University, AP-HP
Cognition: creative thinking, reasoning, semantic, syntax
Main domain: Cognition
Subdomain :  Clinical & translational neuroscience

Laurent COHEN, Lionel NACCACHE & Paolo BARTOLOMEO’s team explores the neural bases of cognitive functions in humans. They work with both healthy and brain-damaged persons, using behavioral methods and a full panel of brain imaging techniques (anatomical,  functional and diffusion-based MRI, EEG, MEG, intracerebral recordings). Their goal is not only the fundamental deciphering of cognitive functions, but also the development of clinically useful tools for the diagnosis and rehabilitation of patients. For more information
Team “Algorithms, Models and Methods for Images and Signals of the Human Brain ”
Team leader(s)
Olivier COLLIOT PhD, DR2, CNRS
Stanley DURRLEMAN PhD, DR2, INRIA
Methodology and neuroimaging
Main domain: Clinical & translational neurosciences

Olivier COLLIOT & Stanley DURRLEMAN’s team, the ARAMIS team aims to build numerical models of brain diseases from multimodal patient data based on the development of specific data-driven approaches.   The main research axes are
  • Integrate multimodal neuroimaging data (PET, microstructure, ASL) to fully characterize alterations
  • Model the temporal dynamics of disease
  • Model brain networks
  • Integrate imaging with other types of data (in particular omics and clinical data)
For more information
Team “Dynamics of Epileptic Networks and Neuronal Excitability”
Team leader(s)
Stephane CHARPIER PhD, PU,Sorbonne university
Mario CHAVEZ PhD, CR1, CNRS
Vincent NAVARRO MD, PhD, PU-PH, Sorbonne university, AP-HP
Dynamics and physiopathology of neural networks, epilepsy
Main domain: Neurophysiology
Subdomain : Clinical & translational neurosciences

Stéphane CHARPIER, Mario CHAVEZ & Vincent NAVARRO ’s team investigates how the brain can become epileptic (epileptogenesis), how it produces seizures (ictogenesis), and the relationship between neurophysiological activities and clinical semiology. In addition, the team investigates extreme brain conditions with abnormal and sustained electrical activities (isoelectric status and status epilepticus). For more information
Team “Basic to translational neurogenetics”
Team leader(s)
Alexandra DURR MD, PhD, PU-PH, Sorbonne university-AP-HP
Giovanni STEVANIN PhD, DR2, PU, INSERM/EPHE
Physiopathology of neurological disorders
Main domain : Cellular & molecular neurosciences
Subdomain : Clinical & translational neurosciences

Alexandra DURR & Giovanni STEVANIN’s team focus on two groups of neurogenetic diseases, spinocerebellar degenerations – SCD (spastic paraplegias and cerebellar ataxias) and frontotemporal lobar degenerations – FTLD. These rare conditions share clinical, genetic and functional characteristics, such as motor neuron dysfunction but are extremely heterogeneous both in molecular and clinical aspects. For more information
Team “ALS : causes and mechanisms of motor neuron degeneration”
Team leader(s)
Severine BOILLEE PhD, CR1, INSERM
Physiopathology of neurological disorders
Main domain : Cellular & molecular neurosciences
Subdomain : Clinical & translational neurosciences

Séverine BOILLEE’s team investigates mechanisms of motor neuron (MN) degeneration in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease) resulting from pathological interactions between MNs and microglia/macrophages to find therapeutically promising pathways to slow disease progression through two main aims: For more information
Team “Neurophysiology of Repetitive Behaviors”
Team leader(s)
Eric BURGUIERE PhD, CR1, CNRS
Basal ganglia, neurosurgery, movements disorders
Main domain: Neurophysiology
Subdomain : Cognition

Eric BURGUIERE’s team aims to implement an ambitious translational approach to characterize neurofunctional basis of normal and pathological repetitive behaviors. The main focus of the team is to study neurophysiological dynamics underlying the automatization of motivated behaviours and its contextual adaptation. The team has access to both patients and animal models suffering from pathological repetitive behaviors. For more information