Research Teams

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Team “Myelin plasticity and regeneration”
Team leader(s)
Brahim NAIT OUMESMAR PhD, DR2, INSERM
Violetta ZUJOVIC PhD, CR1, INSERM
Repair
Main domain: Cellular & molecular neurosciences
Subdomain : Clinical & translational neurosciences

Brahim NAIT OUMESMAR & Violetta ZUJOVIC’s team aims at providing better insight into the mechanisms of myelin plasticity and regeneration. Compelling evidences indicate that oligodendrocyte progenitor cells (OPCs) sense neuronal activity and immune cells signaling, highlighting the importance of these crosstalk’s in (re)-myelination. Therefore, our research project will rely on three major aims to decipher:
  • The role of i)neuronal activity and ii) immune cells in oligodendrocyte differentiation, regeneration and myelin repair, unraveling their relevance in human oligodendrocyte differentiation;
  • To develop innovative tools to identify and assess the therapeutic value of new pro-myelinating compounds.
For more information
Team “Motivation, brain and behavior”
Team leader(s)
Sebastien BOURET PhD, CR2, CNRS
Jean DAUNIZEAU PhD,CR1, INSERM
Mathias PESSIGLIONE PhD, DR2, INSERM
Goal directed behavior, social, moral cognition, motivation
Main domain: Cognition

Mathias PESSIGLIONE, Jean DAUNIZEAU & Sébastien BOURET’s team aims to build a neuro-computational model of how the brain motivates behavior, which would explain irrational behaviors in the normal population, and motivational disorders in pathological conditions. For more information
Team “Normal and abnormal motor control: movement disorders and experimental therapeutics”
Team leader(s)
Stephane LEHERICY MD, PhD, PU-PH, Sorbonne University, AP-HP
Marie VIDAILHET MD, PU-PH, Sorbonne University, AP-HP
Basal ganglia, neurosurgery, movements disorders
Main domain: Neurophysiology
Subdomain: Clinical & translational neurosciences

Marie VIDAILHET & Stéphane LEHÉRICY’s team aims at further investigating network dysfunctions in movement and behavioral disorders using translational, neuroimaging, neurophysiological, and genetic/metabolic approaches from animals to patients. For more information
Team “Sensory Spinal Signaling ”
Team leader(s)
Claire WYART PhD, CR1, INSERM
Spinal circuits underlying locomotion
Main domain: Neurophysiology
Subdomain : Molecular & cellular neuroscience

Claire Wyart’s team investigates the neuromodulatory pathway coming from the brain and within the spinal cord and its effects on locomotion and posture. The team is interested in the circuits referred to as reticulospinal neurons (RSNs) that trigger locomotion in the hindbrain. For more information
Team “Genetics and development of nervous system tumors”
Team leader(s)
Marc SANSON MD, PhD, PU-PH, Sorbonne University, AP-HP
Emmanuelle HUILLARD PhD, CRCN, CNRS
Brain tumors
Main domain : Cellular & molecular neurosciences
Subdomain :  Clinical & translational neurosciences

Marc SANSON & Emmanuelle HUILLARD’s team proposes to identify new mutations and biomarkers, and understand the development of brain tumors with four major aims:
  • To improve diagnosis and treatment by expanding their molecular database and feed new translational projects
  • To characterize the function of newly identified mutations in gliomas by using the “mutation to function” pipeline successfully implemented by the team.
  • To characterize the cell intrinsic and environmental mechanisms governing brain tumor initiation and progression.
  • To develop new mouse and patient-derived models to identify actionable targets and new treatments.
For more information