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Cellular mechanisms of sensory processing

Presentation

Sensory information processing is a basic feature of our brain that is crucial for our everyday actions. Interestingly most of this rather essential brain function relies on the performance of its fundamental functional unit composed by the neuron and its synaptic connections.

 

The diversity of structure and function of neuronal connections (synapses) together with the large number of neurons and synapses (around 10000 per individual cortical neuron) renders brain research rather challenging. In fact, the cellular and molecular mechanisms implicated in information processing by our brain are still largely unknown.

The goal of our laboratory is to investigate the cellular and molecular mechanisms that impact sensory information processing by our brain and how ultimately influence behaviour.

To achieve this important goal we use an array of genetic, optogenetic and pharmacological tools to manipulate neuronal activity both in vivo and in vitro in combination with imaging (Two-photon) and electrophysiological techniques.

We hope that our work will contribute not only to a better understanding of the mechanisms underlying brain function but also to open new avenues to treat neurological diseases such as autism, schizophrenia and epilepsy.

We are presently recruiting. Please submit your CV to nelson.rebola@icm-institute.org

 

 

Main publications

  • Rebola N, Carta M, Mulle C, Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding. Nat, Rev. Neurosci. 2017 Apr;18(4):208-220.
  • Vergnano AM*, Rebola N*, Savtchenko L*, Casado M, Kieffer B, Rusakov D, Mulle C and Paoletti P, Zinc dynamics and action at excitatory synapses, Neuron 2014, 82(5):1101-14. *-Co-first authors
  • Carta M*, Lanore F*, Rebola N*, Szabo Z, Viana Da Silva S, Lourenço J, Verraes A, Nadler A, Schultz C, Blanchet C, Mulle, C. Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels, Neuron. 2014, 81(4):787-99. *-Co-first authors
  • Rebola N, Carta M, Lanore F, Blanchet C, Mulle C. NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses. Nature Neurosci. 2011Jun.;14(6):691–3.
  • Rebola N, Luján R, Cunha RA, Mulle C. Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses. Neuron. 2008 Jan.;57(1):121–34.
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