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Team “Cellular physiology of cortical microcircuits”

Presentation

Main domain : Neurophysiology

Alberto Bacci’s team investigates the microcircuits of the cerebral cortex. In particular, the team is interested in the synaptic and plasticity properties of synapses originating from a highly diverse population of neurons forming stereotyped cortical circuits. To this aim, the lab uses a battery of ex vivo and in vivo neurophysiological approaches.


Four major projects:

  • The identification of layer- and interneuron-specific forms of plasticity, their molecular mechanisms and functional roles
  • The functional role of an elusive inhibitory interneuron subtype during sensory processing
  • The search of the cellular and molecular determinants of dendritic inhibitory synapses;
  • The identification of the physiological role of perineuronal nets (PNNs) and the synaptic mechanism by which they restrict cortical plasticity

Major publications

Contact

alberto.bacci@icm-institute.org

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Team members

  • Joana LOURENÇO

    Principal investigator, PhD, CR2, INSERM

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  • Laurence CATHALA

    Principal investigator, PhD, MCU, Sorbonne Université

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