Eric BURGUIERE’s team aims to implement an ambitious translational approach to characterize neurofunctional basis of normal and pathological repetitive behaviors.The main focus of the team is to study neurophysiological dynamics underlying the automatization of motivated behaviours and theircontextual adaptation. The team has access to both patients and animal models suffering from pathological repetitive behaviorssuch as compulsion/impulsion and stereotypies.
The three main objectives are:
- To characterize the behavioural componentsunderlying normal and pathological repetitive behaviors
- To determine the neural circuits which participate to the acquisition and regulation of repetitive behaviors
- To identify the micro-circuitry whichmodulatethe neural activity within these circuits.
- Burguière E, Monteiro P, Feng G, Graybiel AM. Optogenetic stimulation of lateral orbitofrontostriatalpathway suppresses compulsive behaviors.
Science, 2013 Jun 7;340(6137):1243-6. IF=34.7
- Burbaud P, Clair AH, …, Welter ML, Mallet L. Neuronal activity correlated with checking behaviourin the subthalamic nucleus of patients with obsessive-compulsive disorder.
Brain, 2013 Jan;136(Pt 1):304-17. IF=10.1
- Domenech P, Redoute J, Koechlin E and Dreher JC. The Neuro-Computational Architecture ofValue-Based Selection in the Human Brain.
Cerebral Cortex, 2017 Jan; 1-17. IF=8.3
- Mondragon, L., & Burguiere, E. Bio-inspired benchmark generator for extracellular multi-unitrecordings. Scientific Reports, 2017 Jan; 7, 43253. IF=5.2
- Welter ML, Houeto JL, Thobois S, …, Jalenques I, Karachi C, Mallet L. Anterior pallidal deep brain stimulation for Tourette’s syndrome: a randomised, double-blind, controlled trial.
Lancet Neurology 2017, S1474-4422(17)30160-6 IF=26.3