Presentation
This will:
- Improve the limited understanding of the neurophysiological role of mitochondria in maintaining synaptic metabolic integrity
- Provide a solid molecular framework to unravel the poorly understood molecular link between mitochondrial dysfunction and metabolic epilepsies.
- Help frame future investigations focused on improving mitochondrial bioenergetics in neurological diseases caused by dysfunctional mitochondria.
Major Publications
- Ashrafi, G.*, de Juan-Sanz, J*, Farrell, R.J. and Ryan T.A. (2020). Molecular
tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic
flexibility of neurotransmission. Neuron, 105(4):678-687.e5. * Co-first
authors. - De la Rocha-Muñoz, A., Núñez, E., Gómez-López, S., López-Corcuera B.,
de Juan-Sanz J* and Aragón C (2020). The presynaptic glycine
transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in
vivo. * Corresponding author. BioRxiv.doi:https://doi.
org/10.1101/2020.07.28.224659. - De la Rocha-Muñoz A., Núñez, E., Arribas-González, E., López Corcuera,
B., Aragón, C* and de Juan-Sanz J* (2019). E3 ubiquitin ligases LNX1 and
LNX2 are major regulators of the presynaptic glycine transporter GlyT2. *
Co-corresponding authors. Scientific Reports. Sci Rep 9, 14944 - Koopmans F, van Nierop P, Andres-Alonso M, (…) Malenka R, Nicoll RA,
Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, (…) Thomas PD, Smit AB,
Verhage M (2019). SynGO: An Evidence-Based, Expert-Curated
Knowledge Base for the Synapse. Neuron, 103(2):217-234 - De Juan-Sanz, J., Holt, G. T., Schreiter, E. R., de Juan, F., Kim, D. S., & Ryan,
T. A. (2017). Axonal endoplasmic reticulum Ca 2+ content controls
release probability in CNS nerve terminals. Neuron, 93(4), 867-881
