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Team “FRONTLAB: Frontal systems, functions and dysfunctions”

Presentation

ImpressionBruno Dubois & Richard Levy ‘s team “The FRONTlab” develops research programs focused on the functional anatomy of the prefrontal cortex (PFC) in human and, particularly, on its involvement in the generation of goal-directed behavior (through a research program on apathy as a pathological model), on creative thinking and analogical reasoning (how the rostral PFC is required to link distant knowledge) and language (how the PFC creates and controls combinatory processes). The lab is using different methodological approaches from experimental psychology to state-of-the heart imaging technique analyses (fMRI, voxel-based lesion-symptom mapping, tractography) and surface neurostimulation (TMS & TDCS) applied to both healthy volunteers and patients with focal brain damage or neurodegenerative diseases.

   

Major publications

J. Lagarde, R. Valabergues, J.C. Corvol, B. Garcin, E. Volle, I. Le Ber, M. Vidailhet, B. Dubois, R. Levy (2015) Why do patients with neurodegenerative frontal syndrome fail to answer the following question: “In what way are an orange and a banana alike?”. Brain Dec 16. pii: awu359.

Quentin, R., Elkin Frankston, S., Vernet, M., Toba, M.N., Bartolomeo, P., Chanes, L. & Valero-Cabré, A (2015). Visual Contrast Sensitivity Improvement by Right Frontal High-Beta Activity Is Mediated by Contrast Gain Mechanisms and Influenced by Fronto-Parietal White Matter Microstructure. Cerebral Cortex, 6 (6):2381-90

Teichmann M, Lesoil C, Godard J, Vernet M, Bertrand A, Levy R, Dubois B, Lemoine L, Truong DQ, Bikson M, Kas A, Valero-Cabré A (2016) Direct current stimulation of the anterior temporal lobes boosts primary aphasia. Ann Neurol doi: 10.1002/ana.24766. [Epub ahead of print]

Thiebaut de Schotten, M. Urbanski, B. Batrancourt, R. Levy, B. Dubois, L. Cerliani, E. Volle (2016). Rostro-caudal architecture of the frontal lobes in humans. Cereb Cortex [Epub ahead of print]

M. Urbanski, M.-L. Bréchemier, B. Garcin, D. Bendetowicz, C. Foulon, M. Thiebaut de Schotten, C. Rosso, F. Clarençon, S. Dupont, P. Pradat, M.-A. Labeyrie, R. Levy, E. Volle (2016) Reasoning by analogy requires the left frontal pole: lesion-deficit mapping and clinical implications. Brain 139(Pt 6):1783-99. doi: 10.1093/brain/aww072 

 

 

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Team members