TEAM “Structural dynamics of networks"

Scientific Teams

TEAM “Structural dynamics of networks”

Presentation

CNS development and plasticity Main domain : Cellular & molecular neurosciences Nicolas RENIER’s plans to develop and use cutting-edge 3D whole brain imaging and genetic tools aimed at elucidating how neuronal networks in the adult brain can be rewired at a large scale. The team will :

Investigate the molecular mechanisms of axon and branch dynamics in the adult brain
Gain new information on neuro-vascular interaction during plastic events
Develop correlative 3D imaging of live calcium imaging in the behaving animal with whole brain mapping of neuronal markers and connectivity
Determine the role of structural plasticity to support transitions in behavior in the mouse.

Major Publications

Kirst, C., Skriabine, S., Vieites-Prado, A., Topilko, T., Bertin, P., Gerschenfeld, G., Verny, F., Topilko, P., Michalski, N., Tessier-Lavigne, M., Renier, N. (2020). Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature Cell 180(4), 780-795.e25. (IF=28.7).
Renier N., Dominici C., Erzurumlu R.S., Kratochwil C.F., Rijli F.M., Gaspar P. & Chédotal A. (2017). A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex. eLife, 6, 700. (IF=8.3).
Renier N.*, Adams E. L.*, Kirst C.*, Wu Z.*, Azevedo R., Kohl J., et al. (2016). Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes. Cell, 165(7), 1789–1802. (IF=28.7).
Renier N.*, Wu Z.*, Simon D.J., Yang J., Ariel P., & Tessier-Lavigne M. (2014). iDISCO: a simple,rapid method to immunolabel large tissue samples for volume imaging. Cell, 159(4), 896–910. (IF=28.7).
Xu K.*, Wu Z.*, Renier N.*, Antipenko A., Tzvetkova-Robev D., Xu Y., et al. (2014). Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science, 344(6189), 1275–1279. (IF=34.7).