Presentation
The main objectives are:
- To study how inner physiological states via neuromodulation and release of peptides change the activity of brainstem neurons;
- To pursue the investigation of the mechanisms linking CSF and body-axis formation, scoliosis and host defense;
- To constitute novel translational paths providing insights into the mechanisms of recovery after torsion of the spine, spinal injury or pathogen invasion in the CSF.
Major publications
- Antinucci*, P, Dumitrescu*, AS, Deleuze, C, Morley, HJ, Leung, K, Hagley, T, Kubo, F, Baier, H, Bianco, IH#, Wyart, C#. A calibrated optogenetic toolbox of stable zebrafish opsin lines, eLife 2020;9:e54937.
- Orts-Del’Immagine, A, Cantaut-Belarif, Y,*, Thouvenin, O, Roussel, J, Baskaran, A, Langui, D, Koeth, F, Bivas, P, Lejeune, FX, Bardet, PL, WYART C# [2020]. Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo. Current Biology.
- Thouvenin, O, Keiser, L, Cantaut-Belarif, Y, Carbo-Tano, M, Verweij, F, Jurisch-Yaksi, N, Bardet, PL, Van Niel, G, Gallaire, F, Wyart, C# [2020]. Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLife, pii: e47699.
- Sternberg, JR, Prendergast, AE#, Brosse, L, Cantaut-Belarif, Y, Thouvenin, O, Orts-Dell’Immagine, A, Castillo, L, Djenoune, L, Kurisu, S, McDearmid, JR, Bardet, PL, Boccara, C, Okamoto, H, Delmas, P, Wyart, C # [2018] Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9:3804
- Cantaut-Belarif Y, Sternberg J, Thouvenin O, WYART C#, Bardet PL# [2018]. The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis [2018]. Current Biology 28:2479-2486.e4.
Contact
claire.wyart@icm-institute.org