The main objectives are:
- To study how inner physiological states via neuromodulation and release of peptides change the activity of RSNs and CSF-contacting neurons.
- To pursue the investigation of the mechanisms linking CSF and body-axis formation, scoliosis and host defense.
- To constitute new translational paths involving the Prof. Moussellard in order to provide new insights into the mechanisms of recovery after torsion of the spine, spinal injury or pathogen invasion in the CSF.
- Taking a Big Step towards Understanding Locomotion. Wyart C.Trends Neurosci. 2018 Dec;PMID: 30471663
- Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del’Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C. Nat Commun. 2018 Sep. PMID: 30228263
- Investigation of hindbrain activity during active locomotion reveals inhibitory neurons involved in sensorimotor processing. Severi KE, Böhm UL, Wyart C. Sci Rep. 2018 Sep. PMID: 30206288
- The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis. Cantaut-Belarif Y, Sternberg JR, Thouvenin O, Wyart C, Bardet PL. Curr Biol. 2018 Aug. PMID: 30057305
- Active mechanosensory feedback during locomotion in the zebrafish spinal cord. Knafo S, Wyart C. Curr Opin Neurobiol. 2018 Oct. PMID: 29704750