iCONICS : the bioinformatics and biostatistics core facility

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The iCONICS platform is running three types of activities: “Databases and Datawarehouse”, “Genomics/ Bioinformatics” and “Biostatistics”. The “Databases and Datawarehouse” division develops databases with secure web interfaces, supported by a shared data model that covers a variety of domains (e.g., clinics, biology, genetics, images…). Data is then cross-referenced in a datawarehouse to visualize dynamic reports. The “Genomics/Bioinformatics” division builds and runs pipelines to process and interpret a range of genetics and (epi)genomics data, from high-throughput sequencing analyses (e.g., whole- exome sequencing, RNA-seq, Methyl-seq) and array analyses (e.g. GWAS). The “Biostatistics” division provides basic support in statistical data analysis and designs advanced statistical methods to deal with the integrative analysis of high-dimensional and multimodal data. The platform provides scientists and physicians with both an analytical support (study design, data processing and interpretation) and Web- based services (e.g. transcriptomics data exploration, brain lesion characterization from neuroimaging data). iCONICS is part of the ICM core facility network and supported by the IHU-A-ICM.

ACTIVITIES

• Databases and Datawarehouse:
Information system architecture for databases and associated files
Installing and modeling databases anddatawarehouse
Development of secure web interfaces anddynamic reports
Development of data treatments for data quality

•Bioinformatics/Biostatistics:
Provide methodological advice and expert assistance in the design and interpretation of biomedical studies
Define, implement and make accessibleprocedures and software for processing high- throughput omics data (genetic variants, gene expression, methylation profile, chromatin accessibility)
Elaborate and apply statistical methodologies(especially integrative strategies for multimodal data analysis)

EQUIPMENT

• Databases and Datawarehouse:
ICM IT infrastructure with NAS and SAN storage
Oracle and Informatica Powercenter software
Tableau software, desktop and server

• Bioinformatics/Biostatistics:
600-core computing cluster (ICM IT department)
BladeSystem to host application servers for bioinformatics solutions

TEAM

Stanley Durrleman — Scientific manager
Ivan Moszer — Operational manager
Laure Seux — Databases and Datawarehouse
Christiane Metzinger – Data manager INSIGHT
Justine Guégan — Genomics/transcriptomics
Damien Ulveling — Genomics/epigenomics
Thomas Gareau — Software development
François-Xavier Lejeune – Biostatistics
Vincent Perlbarg — Neuroimaging/data integration
Arthur Tenenhaus — Data integration

CONTACT

iconics@icm-institute.org