Scientific Teams

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Team “Brain Development”
Team leader(s)
Bassem HASSAN Team leader
Bassem Hassan’s team focuses on understanding the genetic mechanisms that regulate the early development of the nervous system from cell fate specification to neural circuit formation, to mechanisms of neural disease using Drosophila fruit flies as a model. For more information
Team “Treatment of Amyotrophic Lateral Sclerosis: from genetics to zebrafish”
Team leader(s)
Edor KABASHI Team leader
Edor Kabashi’s team is aiming to identify novel genetic causes in Amyotrophic Lateral Sclerosis (ALS) and to develop mutant transgenic zebrafish models for these genes to study neurodegenerative processes. This approach also allows the team to use these genetic models for multigenic interactions and drug discovery. Our team has developed innovative screening protocols to identify neuroprotective compounds, to understand molecular mechanisms modulated by these compounds and to advance therapy development in neurological diseases. This project aims at accelerating transition from lab bench to bedside by defining therapeutic avenues for neurodegenerative diseases. For more information
Team “Cellular physiology of cortical microcircuits”
Team leader(s)
Alberto BACCI Team leader
Alberto Bacci’s team aims at gaining more detailed information on the properties of neocortical interneurons, using a combination of electrophysiological, cellular, biochemical and morphological techniques. The ultimate goal of his research is to understand the functional relevance of these different neuron subtypes within cortical circuits. For more information
Team “Alzheimer’s and prion diseases”
Team leader(s)
Stephane HAIK Team leader Contact by email
Marie-Claude POTIER Team leader
Marie-Claude Potier’s and Stéphane Haïk’s group aims at understanding the role of lipids, particularly cholesterol and ApoE, in the secretion and neuronal transport, of AB, their involvement in endosomal modifications that occur early during the course of the disease and novel mechanisms of AB toxicity identified in vivo. Stephane Haïk’s group studies the development of pre-mortem diagnostic procedures for Prion’s disease, the characterization of classical and emerging human prion strains, the understanding of the molecular and cellular mechanisms underlying prion strain selection, propagation and pathogenicity in the human brain. For more information
Team “Genetics and physiopathology of epilepsy”
Team leader(s)
Stephanie BAULAC Team leader
Eric LEGUERN Team leader
Eric Leguern and Stephanie Baulac’s team are passionate about the familial epileptic syndromes which, additionally to being a significant health problem, are one of the most straightforward and reliable way to identify novel key proteins and pathways of epileptogenesis and ictogenesis. The main goal of the research is to understand the molecular and cellular mechanisms underlying genetic epilepsies, in particular familial focal epilepsies, focal cortical dysplasias, epileptic encephalopathies associated with febrile seizures, and genetic generalized epilepsies.   The research work combines high-throughput sequencing, transcriptomics, in utero electroporation, biochemistry, electrophysiology, and animal studies. Functional analyses are made on human postoperative tissue and neuronal cultures from specific rodent models. We apply modern techniques based on single-cell approaches, CRISPR/Cas9 editing, and multielectrode array recordings.   The team collaborates with several researchers in the USA (M. Meisler, M. Anderson) and in Japan (T. Mashimo, T. Serikawa) and is part of European projects and consortiums: the EPICURE project (2006-2011) and the EuroEPINOMICS consortium (since 2011). For more information
Team “Social and affective neuroscience”
Team leader(s)
Philippe FOSSATI Team leader
Nathalie GEORGE Team leader
The SAN (Social and Affective Neuroscience) team gathers together three PIs with complementary expertise in affective neuroscience, social neuroscience, and psychiatry, with the aim of understanding the neural mechanisms by which social processes activate and regulate the emotional brain. For more information
Team “Experimental neurosurgery”
Team leader(s)
Brian LAU Team leader
Parkinson Disease (PD) results in severe motor dysfunction that is alleviated by deep brain stimulation (DBS) of the Subthalamic nucleus (STN), but debilitating side effects are observed in some cases. Yet, the function of the STN remains unclear, making it difficult to interpret the effects of DBS. A detailed understanding of the role of the STN in voluntary movements is necessary for developing new treatments for PD. Brian Lau’s aim is to characterize the role of the STN and to understand how information flow from the cortex shapes activity in the STN. For more information
Team “Mechanisms of myelination and remyelination in the CNS”
Team leader(s)
Catherine LUBETZKI Team leader
Bruno STANKOFF Team leader
Catherine Lubetzki’s and Bruno Stankoff’s team focuses on the pathophysiology of multiple sclerosis (MS), notably the mechanisms of CNS myelination and remyelination and aims at translating gained insights into clinical practice. For more information
Team “Molecular and cellular mechanisms of glioma genesis”
Team leader(s)
Emmanuelle HUILLARD Team leader
Emmanuelle Huillard’s team is interested in understanding the cellular and molecular cascades that underlie the formation of high-grade gliomas such as Glioblastoma (GBM). GBM is the most aggressive form of glioma, the most common primary brain cancer in adults. GBM is notoriously resistant to standard radiotherapy and chemotherapy treatments and thus represent a leading cause of cancer-related death worldwide. For more information
Team “Experimental therapeutics of Parkinson’s disease”
Team leader(s)
Etienne HIRSCH Team leader
Etienne Hirsch’s team focuses the neuro-immune pathological interactions in Parkinson Disease. The goals are to uncover the identity, origin and function of the various innate and adaptive immune cells involved in response to dopamine (DA) neuron degeneration, investigate the pathological impact of DA lesions on non-DA systems and its reciprocity. Using a combination of clinical, physiological, imaging and transcranial magnetic stimulation studies, the team will decipher the role of non-DA lesions in gait and balance disorders. This project will highlight new symptomatic and curative therapies. For more information