Team "Biotechnology et biotherapy" (Bio-Modeling in Neurodegenerative Diseases)
Judith Gendron is a PhD student in the Biotechnology and Biotherapy team.
After obtaining a BSc in “Sciences & technology” from the University of Paris VI Pierre & Marie Curie, she completed a MRes in “Molecular and Cellular Biology & Therapeutic targets” from UPMC with the co-supervision from Museum National of Natural History. During her Master she worked at the Pasteur Institute on neurodegenerative disease modelling on generating iPSC from patient's fibroblasts by non-integrative episomal transfection & by differentiating them in neural cells. Then Judith joined Philippe Ravassard's team at the ICM in 2013 to study dynamical expression of long non-coding RNAs expressed (i) in developing serotoninergic neurons and (ii) in pancreatic beta cells during gestation. These preliminary studies led her to her PhD project detailed below.
She obtained a PhD scholarship from the University Pierre & Marie Curie to work in Philippe Ravassard's team at the ICM. She also works at the European funding office (1/5 of the time).
Judith is studying the transcriptome and non-coding elements of the genome from dopaminergic & serotoninergic neurons, focusing on open & active chromatin regions, as well as long non-coding RNA repertoire, using ATAC-sequencing and RNA-Sequencing. She also analyses the potential contribution of the non-coding elements identified in dopaminergic neurons to Parkinson’s disease. This work is carried out on dopaminergic & serotoninergic murine neurons and dopaminergic neurons differentiated from human iPSC.
This project is funded by the Edmond J. Safra Foundation & the foundation for the medical research.